Patients with normocalcemic primary hyperparathyroidism may have similar metabolic profile as hypercalcemic patients

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Normocalcemic versus Hypercalcemic Primary Hyperparathyroidism: More Stone than Bone?

Introduction. Normocalcemic primary hyperparathyroidism (NPHPT) is considered a variant of the more frequent form of the disease characterized by normal serum calcium levels with high PTH. The higher prevalence of renal stones in patients with HPTP and the well established association with bone disorders show the importance of studies on how to manage asymptomatic patients. Objective. To compar...

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Chronic constipation in hypercalcemic patients with primary hyperparathyroidism.

BACKGROUND Chronic constipation (C), among gastrointestinal symptoms, is commonly associated with primary hyperparathyroidism (PHPT) and probably attributable to hypercalcemia. OBJECTIVE OF THE STUDY To evaluate in patients affected with PHPT the prevalence of C utilizing a validated questionnaire and the current prevalence of C compared to that observed in the past and to evaluate the relati...

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Normocalcemic Primary Hyperparathyroidism

Normocalcemic Primary Hyperparathyroidism (NC-PHPT) is a clinical entity characterized by normal serum calcium and persistently elevated parathyroid (PTH) levels. These patients have no obvious causes for secondary hyperparathyroidism such as vitamin D deficiency and renal insufficiency [1,2-16,17]. None of the patients had clear evidence of gastrointestinal disease. Although the entity NC-PHPT...

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Normocalcemic primary hyperparathyroidism.

Primary hyperparathyroidism, a common endocrine disorder, is traditionally defined by hypercalcemia and elevated levels of parathyroid hormone (PTH). A newer presentation of primary hyperparathyroidism has been described over the past decade, in which PTH is elevated but serum calcium is consistently normal, in the absence of secondary causes of hyperparathyroidism, such as renal disease or vit...

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Normocalcemic primary hyperparathyroidism is a new entity which possibly represents a fruste form of the classic clinically symptomatic disease and which has generated a considerable scientific interest in the last decade. Its official recognition is just as recent as in 2008, when an international conference took place for clarifying its nature and relevance (Bilezikian et al., 2009). Its true...

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ژورنال

عنوان ژورنال: Endocrine Journal

سال: 2016

ISSN: 0918-8959,1348-4540

DOI: 10.1507/endocrj.ej15-0392